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Unconjugated Rabbit anti-Human CHAF1A (1D4) Monoclonal Antibody [IgG]
Výrobca: Bioss Katalógové č .: bsm-54414R Aplikácie: Imunofluorescencia, Imunohistochémia, Imunoprecipitácia, imunoaglutinácia, Prietoková cytometria, Western Blot Reaktivita: Human Pôvod: Rabbit Klonalita: Monoclonal Podtrieda: IgG Status: RUO Dodatočné informácie: Produkt na webe výrobcu Popis:Chromatin assembly factor 1 subunit A; Chromatin assembly factor I p150 subunit; CAF-1 subunit A; CAF-I 150 kDa subunit; CAF-I p150; hp150; p150 CAF1
Core component of the CAF-1 complex, a complex thought to mediate chromatin assembly in DNA replication and DNA repair. Assembles histone octamers onto replicating DNA in vitro. CAF-1 performs the first step of the nucleosome assembly process, bringing newly synthesized histones H3 and H4 to replicating DNA; histones H2A/H2B can bind to this chromatin precursor subsequent to DNA replication to complete the histone octamer. CHAF1A binds to histones H3 and H4. It may play a role in heterochromatin maintenance in proliferating cells by bringing newly synthesized cbx proteins to heterochromatic DNA replication foci.